Rochester General Hospital Edition
In 2014, the National Institutes of Health announced a pause on funding for research that could enhance the transmission or pathogenicity of certain viruses, also called “gain of function” research. The pause was removed in December 2017 after a lengthy risk-benefit analysis. Proponents of these studies argue there are significant potential gains from exploration of how these viruses spread; while critics worry the risk of accidentally seeding a pandemic outweighs the rewards.
- Notice announcing the removal of the funding pause for gain-of-function research. National Institutes of Health.
- Does influenza pandemic preparedness and mitigation require gain-of-function research? Adam DC, Magee D, Bui CM, Scotch M, MacIntyre CR.
- Gain-of-Function Research and the Relevance to Clinical Practice. Kilianski A, Nuzzo JB, Modjarrad K.
- The ethics of biosafety considerations in gain-of-function research resulting in the creation of potential pandemic pathogens. Evans NG, Lipsitch M, Levinson M.
- Gain-of-function experiments: time for a real debate. Duprex WP, Fouchier RA, Imperiale MJ, Lipsitch M, Relman DA.
- Influenza gain-of-function experiments: their role in vaccine virus recommendation and pandemic preparedness. Schultz-Cherry S, Webby RJ, Webster RG, Kelso A, Barr IG, McCauley JW, Daniels RS, Wang D, Shu Y, Nobusawa E, Itamura S, Tashiro M, Harada Y, Watanabe S, Odagiri T, Ye Z, Grohmann G, Harvey R, Engelhardt O, Smith D, Hamilton K, Claes F, Dauphin G.
Bibliography by Rachel Becker, MLIS
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